The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells

0213610 - UZFG-Y 20033079 RIV US eng J - Článek v odborném periodiku
Anger, Martin - Bryja, Vítězslav - Jirmanová, L. - Hampl, Aleš - Carrington, M. - Motlík, Jan - Dvořák, Petr - Kubelka, Michal
The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells.
Biochemical and Biophysical Research Communications. Roč. 302, - (2003), s. 825-830. ISSN 0006-291X. E-ISSN 1090-2104
Grant CEP: GA ČR GA523/00/0780; GA MŠMT LN00A065
Výzkumný záměr: CEZ:AV0Z5045916; CEZ:AV0Z5039906; CEZ:MSM 432100001
Klíčová slova: mouse embryonic stem cell
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 2.836, rok: 2003

The presence of truncated form of cyclin A2 has been reported in various murine cell lines and tissues. In this paper it was shown that while undifferentiated proliferating mouse embryonic stem cells express low levels of this truncated cyclin A2, cells that are induced to differentiate remarkably increase its synthesis. Importantly, the expression pattern of truncated cyclin A2 was the same in p27 -/- ES cells as in the wild-type ES cells. Thus, it suggests that p27 is not necessary for the proteolytic cleavage of cyclin A2 and that this post-translational modification correlates with differentiation.
Trvalý link: http://hdl.handle.net/11104/0109145