Cell cycle dependent expression of Plk 1 in synchronized porcine fetal fibroblasts
1.
SYSNO ASEP
0173866
Druh ASEP
J - Článek v odborném periodiku
Zařazení RIV
J - Článek v odborném periodiku
Poddruh J
Ostatní články
Název
Cell cycle dependent expression of Plk 1 in synchronized porcine fetal fibroblasts
Tvůrce(i)
Anger, M. (US) Kues, W. A. (DE) Klíma, J. (CZ) Mielenz, M. (DE) Kubelka, M. (CZ) Motlík, J. (CZ) Ešner, M. (CZ) Dvořák, Petr (UEM-P) Carnwath, J. W. (DE) Niemann, H. (DE)
Zdroj.dok.
Molecular Reproduction and Development
- ISSN 1040-452X
Roč. 65, - (2003), s. 245-253
Poč.str.
9 s.
Jazyk dok.
eng - angličtina
Země vyd.
US - Spojené státy americké
Klíč. slova
serum deprivation
Vědní obor RIV
EB - Genetika a molekulární biologie
CEP
LN00A065 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ
AV0Z5039906 - UEM-P
Anotace
Enzymes of the Polo-like kinase family are active in the pathways controlling mitosis in several species. CDNA fragments of the porcine homologues of Plk1, Plk2, and Plk3 were cloned. All three cDNAs show high sequence homology with their mouse and human counterparts and contain the Polo box. In synchronized porcine fetal fibroblasts, Plk1 mRNA was barely detectable in G0 and G1, increased during S phase and peaked after G2/M transition. Porcine Plk1 protein was detected at the beginning of S phase and was highest after the G2/M transition. In summary, the Plk1 expression pattern in the pig is similar to that reported for other species.
