Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells
1.
SYSNO ASEP
0173635
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells
Author(s)
Tvrdík, Daniel (UEM-P) Djaborkhel, Rashed (UEM-P) Nagy, Alexandr (UEM-P) Eckschlager, T. (CZ) Raška, Ivan (UEM-P) Müller, Julius (UEM-P)
Source Title
Journal of Structural Biology. - : Elsevier
- ISSN 1047-8477
Roč. 140, - (2002), s. 49-56
Number of pages
8 s.
Language
eng - English
Country
US - United States
Keywords
cyclin-dependent kinase ; follicular lymphoma ; retinoblastoma protein
Subject RIV
EA - Cell Biology
R&D Projects
GA304/01/0564 GA ČR - Czech Science Foundation (CSF)
CEZ
AV0Z5039906 - UEM-P
MSM 111100003
Annotation
The kinase activity of cdk2, cdk4, and cdk6 was significantly reduced and hypophosphorylation of pRb on serine 795 (S795) and threonine 373 (T373) was observed. Both cdk4 and cdk6 were notably dissociated from cyclin D co-factors, while cyclin E-cdk2 complexes remained coupled in TGFß1-treated cells. TGFß1-induced growth arrest was associated with notably increased binding of p21WAF1 to cdk4 and cdk6.
