Therapeutic drug monitoring of albendazole: Determination of albendazole, albendazole sulfoxide, and albendazole sulfone in human plasma using nonaqueous capillary electrophoresis
1.
SYSNO ASEP
0162188
Druh ASEP
J - Článek v odborném periodiku
Zařazení RIV
J - Článek v odborném periodiku
Poddruh J
Ostatní články
Název
Therapeutic drug monitoring of albendazole: Determination of albendazole, albendazole sulfoxide, and albendazole sulfone in human plasma using nonaqueous capillary electrophoresis
Tvůrce(i)
Procházková, Andrea (UIACH-O) Chouki, M. (CH) Theurillat, R. (CH) Thormann, W. (CH)
Zdroj.dok.
Electrophoresis. - : Wiley
- ISSN 0173-0835
Roč. 21, č. 4 (2000), s. 729-736
Poč.str.
7 s.
Jazyk dok.
eng - angličtina
Země vyd.
DE - Německo
Vědní obor RIV
CB - Analytická chemie, separace
CEZ
AV0Z4031919 - UIACH-O
Anotace
A nonaqueous capillary electrophoresis (NACE) for the fast determination of plasma levels of albendazole, albendazole sulfoxide, and albendazole sulfone is described. The assay is based upon liquid/liquid extraction of these compounds using dichlormethane (pH 10.2), followed by a NACE separation performed using a 0.036 M borate buffer (apparent pH 9.9) in a mixture of methanol and N-methylformamide (1:3) and on-column absorbance detection at 280 nm. The reliability of the method developed was verified via analysis of 45 plasma samples obtained from patients treated with albendazole.