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Fos expression in spinothalamic and postsynaptic dorsal column neurons following noxious visceral and cutaneous stimuli
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SYSNO ASEP 0142477 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Fos expression in spinothalamic and postsynaptic dorsal column neurons following noxious visceral and cutaneous stimuli Tvůrce(i) Paleček, Jiří (FGU-C) RID, ORCID
Palečková, V. (US)
Willis, W. D. (US)Zdroj.dok. Pain. - : Lippincott Williams & Wilkins - ISSN 0304-3959
Roč. 104, 1-2 (2003), s. 249-257Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova visceral pain ; myelotomy ; postsynaptic dorsal column Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEP GA309/03/0752 GA ČR - Grantová agentura ČR CEZ AV0Z5011922 - FGU-C Anotace Fos protein expression in retrogradely labeled spinothalamic tract (STT) and postsynaptic dorsal column (PSDC) neurons in the lumbosacral enlargement in rats was used as an anatomical marker of enhanced activation to compare the role of these neurons in cutaneous and visceral pain. The noxious stimuli used were intradermal injection of capsaicin and distention of the ureter. Retrogradely labeled neurons were found in laminae III-IV and in the vicinity of the central canal. STT neurons were located in laminae I, III-VII and X. Ureter distention evoked Fos expression in PSDC and STT neurons located in all laminae in which retrogradely labeled cell were found, with the maximum in the L2 spinal segment. The Fos-positive PSDC neurons represented a significantly higher percentage of the retrogradely labeled neurons than of the STT Fos-positive neurons. Intradermal capsaicin injection also evoked Fos expression in both PSDC and STT neurons, but with no significant difference between these two. These results show that both PSDC and STT neurons are activated by cutaneous and visceral noxious stimuli. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2004
Počet záznamů: 1