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Tumour-initiating cells vs. cancer "stem" cells and CD133: What's in the name?
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SYSNO ASEP 0096517 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Tumour-initiating cells vs. cancer "stem" cells and CD133: What's in the name? Překlad názvu Buňky iniciující nádory či rakovinné "kmenové" buňky a CD133: co je po jméně? Tvůrce(i) Neužil, Jiří (UMG-J)
Stantic, M. (AU)
Zobalová, Renata (UMG-J)
Chladová, Jaromíra (UMG-J)
Wang, X. F. (AU)
Procházka, L. (CZ)
Dong, L. (AU)
Anděra, Ladislav (UMG-J) RID
Ralph, S.J. (AU)Zdroj.dok. Biochemical and Biophysical Research Communications. - : Elsevier - ISSN 0006-291X
Roč. 255, č. 4 (2007), s. 855-859Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova tumour-initiating cells ; CD133 ; resistance to treatment Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520514 - UMG-J (2005-2011) AV0Z50520701 - BTO-N (2007-2013) Anotace Recent evidence suggests that a subset of cells within a tumour have "stem-like" characteristics. These tumour-initiating cells, distinct from non-malignant stem cells, show low proliferative rates, high self-renewing capacity, propensity to differentiate into actively proliferating tumour cells, resistance to chemotherapy or radiation, and they are often characterised by elevated expression of the stem cell surface marker CD133. Understanding the molecular biology of the CD133+ cancer cells is now essential for developing more effective cancer treatments. These may include drugs targeting organelles, such as mitochondria or lysosomes, using highly efficient and selective inducers of apoptosis. Alternatively, agents or treatment regimens that enhance sensitivity of these therapy-resistant "tumour stem cells" to the current or emerging anti-tumour drugs would be of interest as well. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2008
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