Microtubular and Nuclear Functions of gamma-Tubulin: Are They LINCed?

0504271 - MBÚ 2020 RIV CH eng J - Článek v odborném periodiku
Chumová, Jana - Kourová, Hana - Trögelová, Lucie - Halada, Petr - Binarová, Pavla
Microtubular and Nuclear Functions of gamma-Tubulin: Are They LINCed?
Cells. Roč. 8, č. 3 (2019), č. článku 259. E-ISSN 2073-4409
Grant CEP: GA ČR GA15-11657S
Grant ostatní: AV ČR(CZ) MSM200201901
Program: Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Institucionální podpora: RVO:61388971
Klíčová slova: gamma-tubulin * nucleation * nuclear functions
Obor OECD: Microbiology
Impakt faktor: 4.366, rok: 2019
Způsob publikování: Open access
https://www.mdpi.com/2073-4409/8/3/259

gamma-Tubulin is a conserved member of the tubulin superfamily with a function in microtubule nucleation. Proteins of gamma-tubulin complexes serve as nucleation templates as well as a majority of other proteins contributing to centrosomal and non-centrosomal nucleation, conserved across eukaryotes. There is a growing amount of evidence of gamma-tubulin functions besides microtubule nucleation in transcription, DNA damage response, chromatin remodeling, and on its interactions with tumor suppressors. However, the molecular mechanisms are not well understood. Furthermore, interactions with lamin and SUN proteins of the LINC complex suggest the role of gamma-tubulin in the coupling of nuclear organization with cytoskeletons. gamma-Tubulin that belongs to the clade of eukaryotic tubulins shows characteristics of both prokaryotic and eukaryotic tubulins. Both human and plant gamma-tubulins preserve the ability of prokaryotic tubulins to assemble filaments and higher-order fibrillar networks. gamma-Tubulin filaments, with bundling and aggregating capacity, are suggested to perform complex scaffolding and sequestration functions. In this review, we discuss a plethora of gamma-tubulin molecular interactions and cellular functions, as well as recent advances in understanding the molecular mechanisms behind them.
Trvalý link: http://hdl.handle.net/11104/0295978