Immunohistochemical Evidence of the Involvement of Natural Killer (CD161(+)) Cells in Spontaneous Regression of Lewis Rat Sarcoma

0503687 - ÚŽFG 2020 RIV NZ eng J - Článek v odborném periodiku
Kovalská, Jana - Červinková, Monika - Chmelíková, E. - Plánská, Daniela - Čížková, Jana - Horák, Vratislav
Immunohistochemical Evidence of the Involvement of Natural Killer (CD161(+)) Cells in Spontaneous Regression of Lewis Rat Sarcoma.
In Vivo. Roč. 33, č. 1 (2019), s. 47-52. ISSN 0258-851X. E-ISSN 1791-7549
Grant CEP: GA MŠMT(CZ) LO1609
Institucionální podpora: RVO:67985904
Klíčová slova: tumour * spontaneous regression * immunohistochemistry
Obor OECD: Immunology
Impakt faktor: 1.541, rok: 2019
Způsob publikování: Open access
http://iv.iiarjournals.org/content/33/1/47.full.pdf

Background/Aim: Spontaneous regression (SR) of tumours is a rare phenomenon not yet fully understood. The aim of this study was to investigate immune cells infiltrating progressive and SR tumours in a Lewis rat sarcoma model. Materials and Methods: Rats were subcutaneously inoculated with rat sarcoma R5-28 (clone C4) cells. Developing tumours were obtained on day 42 and cryosections were immunohistochemically processed for detection of immune cells. Results: A high density of granulocytes was found in the necrotic areas of both progressive and SR tumours. CD4(+) cells and CD8(+) cells were rare and sparsely dispersed in the tumour tissue without clear difference between the two types of tumours. On the contrary, CD161(+) cells were abundant and evenly distributed in SR tumours, but these cells were very rare in progressive tumours. Conclusion: Based on the differences in number and distribution of the immune cell subpopulations, we believe that natural killer (CD161(+)) cells play a major role in the destruction of cancer cells during SR of tumours in this Lewis rat model.
Trvalý link: http://hdl.handle.net/11104/0295497