MOCVD Iron Oxide Nanoparticle Generation not Only for Follow-Up Inalation Exposure Experiments.

0496252 - ÚCHP 2019 RIV CZ eng C - Konferenční příspěvek (zahraniční konf.)
Moravec, Pavel - Schwarz, Jaroslav - Vodička, Petr - Kupčík, Jaroslav - Švehla, Jaroslav
MOCVD Iron Oxide Nanoparticle Generation not Only for Follow-Up Inalation Exposure Experiments.
Sborník XIX. výroční konference České aerosolové společnosti, pp. 44-47. Praha: Česká Aerosolová společnost, 2018 - (Pokorná, P.), s. 80-83. ISBN 978-80-270-4780-2.
[Výroční konference České aerosolové společnosti /19./. Piešťany (SK), 25.10.2018-26.10.2018]
Grant CEP: GA ČR(CZ) GBP503/12/G147
Institucionální podpora: RVO:67985858 ; RVO:61388980
Klíčová slova: exposure studies * iron oxide nanoparticle generation * nanoparticle characterization
Obor OECD: Environmental sciences (social aspects to be 5.7); Inorganic and nuclear chemistry (UACH-T)

Iron oxide nanoparticles (NPs) are industrially produced and commercially available and they are also frequently emitted into the environment by iron making plants. In the human body, iron is maintained at homeostatic fairly low level. However, freshly generated iron oxide NPs cause febrile and inflammatory response known as metal fume fever, but the potential in vivo consequences of inhalation of iron oxide NPs from the atmosphere has not yet been investigated. An overview of recent studies evaluating iron oxide NPs cytotoxicity, genotoxicity, developmental toxicity and neurotoxicity was presented by Valdiglesias et al. (2015). Toxicity of iron oxide NPs has been studied both in vitro and in vivo. Exposure chamber for the whole body inhalation experiments with small laboratory animals was constructed at the Institute of Analytical Chemistry of the CAS (Večeřa et al., 2011) and some methods of NPs generation for these experiments were already tested in our laboratory (Moravec et al., 2015. Moravec et al., 2016). In this study we tested a method of long lasting generation of iron oxide NPs by pyrolysis and oxidation of ironIII acetylacetonate (FeAA3).
Trvalý link: http://hdl.handle.net/11104/0289067