Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View

0478167 - ÚFCH JH 2018 RIV US eng J - Článek v odborném periodiku
Cebecauer, Marek - Hof, Martin - Amaro, Mariana
Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View.
Biophysical Journal. Roč. 113, č. 6 (2017), s. 1194-1199. ISSN 0006-3495. E-ISSN 1542-0086
Grant CEP: GA ČR GA17-03160S
Institucionální podpora: RVO:61388955
Klíčová slova: SURFACE-PLASMON RESONANCE * ALZHEIMERS-DISEASE * GM1 GANGLIOSIDE
Obor OECD: Biophysics
Impakt faktor: 3.495, rok: 2017
Způsob publikování: Open access

In this perspective we summarize current knowledge of the effect of monosialoganglioside GM(1) on the membrane-mediated aggregation of the beta-amyloid (A beta) peptide. GM(1) has been suggested to be actively involved in the development of Alzheimer's disease due to its ability to seed the aggregation of A beta. However, GM(1) is known to be neuroprotective against A beta-induced toxicity. Here we suggest that the two scenarios are not mutually exclusive but rather complementary, and might depend on the organization of GM(1) in membranes. Improving our understanding of the molecular details behind the role of gangliosides in neurodegenerative amyloidoses might help in developing disease-modifying treatments.
Trvalý link: http://hdl.handle.net/11104/0274355