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Humans and great apes cohabiting the forest ecosystem in Central African Republic harbour the same hookworms
- 1.0427111 - ÚBO 2015 RIV US eng J - Článek v odborném periodiku
Hasegawa, H. - Modrý, D. - Kitagawa, M. - Shutt, K. A. - Todd, A. - Kalousová, B. - Profousová, I. - Petrželková, Klára Judita
Humans and great apes cohabiting the forest ecosystem in Central African Republic harbour the same hookworms.
PLoS Neglected Tropical Diseases. Roč. 8, č. 3 (2014), e2715. ISSN 1935-2735. E-ISSN 1935-2735
Grant CEP: GA ČR GA206/09/0927
Institucionální podpora: RVO:68081766
Klíčová slova: Necator spp. * mountain gorillas * infection * chimpanzees * Dzanga-Sangha Protected Areas, Central African Republic
Kód oboru RIV: EG - Zoologie
Impakt faktor: 4.446, rok: 2014
We conducted analyses of DNA sequences obtained from the infective larvae of Necator spp. from humans and great apes inhabiting Dzanga-Sangha Protected Areas, Central African Republic. Three sequence types (I–III) were recognized in the in the ITS region, and 34 cox1 haplotypes represented three phylogenetic groups (A–C). I-A, II-B, II-C, III-B, III-C combinations were determined. Combination I-A, corresponding to Necator americanus, was demonstrated in humans and western lowland gorillas; II-B and II-C were observed in humans (local inhabitants and researchers), western lowland gorillas and chimpanzees; III-B and III-C were found only in humans. Pairwise nucleotide difference in the cox1 haplotypes between the groups was more than 8%, while the difference within each group was less than 2.1%, suggesting that each type represents a distinct species. This is the first molecular evidence that Necator species found in great apes can infect humans and vice versa.
Trvalý link: http://hdl.handle.net/11104/0232722
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