Alkaloids from Boophone haemanthoides (Amaryllidaceae)

0423125 - ÚEB 2014 RIV US eng J - Článek v odborném periodiku
Nair, J. J. - Rárová, L. - Strnad, Miroslav - Bastida, J. - van Staden, J.
Alkaloids from Boophone haemanthoides (Amaryllidaceae).
Natural Product Communications. Roč. 8, č. 12 (2013), s. 1705-1710. ISSN 1934-578X. E-ISSN 1555-9475
Výzkumný záměr: CEZ:AV0Z50380511
Klíčová slova: Alkaloid * Amaryllidaceae * Boophone haemanthoides
Kód oboru RIV: CE - Biochemie
Impakt faktor: 0.924, rok: 2013
http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=CCC&DestLinkType=FullRecord&UT=000328588200011

In this study, the South African Amaryllid Boophone haemanthoides was examined for its phytochemical composition and cytotoxicity. In the process eight alkaloid structures, including the new compound distichaminol, were identified in bulb ethanolic extracts. Of the isolates, lycorine and distichamine exhibited strong activities against human acute lymphoblastic leukemia (CEM), breast adenocarcinoma (MCF7) and cervical adenocarcinoma (HeLa) cells with IC(50)s ranging from 1.8 to 9.2 mu M.
Trvalý link: http://hdl.handle.net/11104/0229213