Počet záznamů: 1  

Immunoengineering strategies to enhance vascularization and tissue regeneration

  1. 1.
    0557599 - FGÚ 2023 RIV NL eng J - Článek v odborném periodiku
    Zárubová, Jana - Hasani-Sadrabadi, M. M. - Ardehali, R. - Li, S.
    Immunoengineering strategies to enhance vascularization and tissue regeneration.
    Advanced Drug Delivery Reviews. Roč. 184, May (2022), č. článku 114233. ISSN 0169-409X. E-ISSN 1872-8294
    Institucionální podpora: RVO:67985823
    Klíčová slova: neutrophils * macrophages * T cells * immunomodulation * cell delivery * extracellular vesicles * biomaterial * immune cell metabolism * stiffness * patterning
    Obor OECD: Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
    Impakt faktor: 16.1, rok: 2022
    Způsob publikování: Omezený přístup
    https://doi.org/10.1016/j.addr.2022.114233

    Immune cells have emerged as powerful regulators of regenerative as well as pathological processes. The vast majority of regenerative immunoengineering efforts have focused on macrophages, however, growing evidence suggests that other cells of both the innate and adaptive immune system are as important for successful revascularization and tissue repair. Moreover, spatiotemporal regulation of immune cells and their signaling have a significant impact on the regeneration speed and the extent of functional recovery. In this review, we summarize the contribution of different types of immune cells to the healing process and discuss ways to manipulate and control immune cells in favor of vascularization and tissue regeneration. In addition to cell delivery and cell-free therapies using extracellular vesicles, we discuss in situ strategies and engineering approaches to attract specific types of immune cells and modulate their phenotypes. This field is making advances to uncover the extraordinary potential of immune cells and their secretome in the regulation of vascularization and tissue remodeling. Understanding the principles of immunoregulation will help us design advanced immunoengineering platforms to harness their power for tissue regeneration.
    Trvalý link: http://hdl.handle.net/11104/0331781

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.