Počet záznamů: 1  

Subtelomeric assembly of a multi-gene pathway for antimicrobial defense compounds in cereals

  1. 1.
    0546298 - ÚEB 2022 RIV GB eng J - Článek v odborném periodiku
    Li, Y. - Leveau, A. - Zhao, Q. - Martin, A. - Wegel, E. - Orme, A. - Karafiátová, Miroslava - Vrána, Jan - Steuernagel, B. - Joynson, R. - Louveau, T. - Stephenson, M. J. - Fan, D. - Zhou, C. - Tian, Q. - Polturak, G. - Casson, R. - Hill, L. - Moore, G. - Melton, R. - Hall, M. - Wulff, B. B. H. - Doležel, Jaroslav - Langdon, T.G. - Han, B. - Osbourn, A. … celkem 44 autorů
    Subtelomeric assembly of a multi-gene pathway for antimicrobial defense compounds in cereals.
    Nature Communications. Roč. 12, č. 1 (2021), č. článku 2563. E-ISSN 2041-1723
    Grant CEP: GA MŠk(CZ) EF16_019/0000827
    Institucionální podpora: RVO:61389030
    Klíčová slova: In Situ Hybridization * Fluorescence * Repetitive Sequences
    Obor OECD: Biochemistry and molecular biology
    Impakt faktor: 17.694, rok: 2021
    Způsob publikování: Open access
    http://doi.org/10.1038/s41467-021-22920-8

    Non-random gene organization in eukaryotes plays a significant role in genome evolution. Here, we investigate the origin of a biosynthetic gene cluster for production of defence compounds in oat—the avenacin cluster. We elucidate the structure and organisation of this 12-gene cluster, characterise the last two missing pathway steps, and reconstitute the entire pathway in tobacco by transient expression. We show that the cluster has formed de novo since the divergence of oats in a subtelomeric region of the genome that lacks homology with other grasses, and that gene order is approximately colinear with the biosynthetic pathway. We speculate that the positioning of the late pathway genes furthest away from the telomere may mitigate against a ‘self-poisoning’ scenario in which toxic intermediates accumulate as a result of telomeric gene deletions. Our investigations reveal a striking example of adaptive evolution underpinned by remarkable genome plasticity.
    Trvalý link: http://hdl.handle.net/11104/0322831

     
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Počet záznamů: 1  

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