Počet záznamů: 1
Roles of the ventral hippocampus and medial prefrontal cortex in spatial reversal learning and attentional set-shifting
- 1.0545464 - FGÚ 2022 RIV US eng J - Článek v odborném periodiku
Černotová, Daniela - Stuchlík, Aleš - Svoboda, Jan
Roles of the ventral hippocampus and medial prefrontal cortex in spatial reversal learning and attentional set-shifting.
Neurobiology of Learning and Memory. Roč. 183, September 2021 (2021), č. článku 107477. ISSN 1074-7427. E-ISSN 1095-9564
Grant CEP: GA MZd NV17-30833A; GA ČR(CZ) GA20-00939S; GA MŠMT(CZ) LTAUSA19135
Grant ostatní: AV ČR(CZ) PAN-20-08
Program: Bilaterální spolupráce
Institucionální podpora: RVO:67985823
Klíčová slova: behavioral flexibility * ventral hippocampus * prefrontal cortex * Muscimol * rotating arena * carousel
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 3.109, rok: 2021
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.nlm.2021.107477
Neural components enabling flexible cognition and behavior are well-established, and depend mostly on proper intercommunication within the prefrontal cortex (PFC) and striatum. However, dense projections from the ventral hippocampus (vHPC) alter the functioning of the medial PFC (mPFC). Dysfunctional hippocampo-prefrontal connectivity negatively affects the integrity of flexible cognition, especially in patients with schizophrenia. In this study, we aimed to test the role of the vHPC and mPFC in a place avoidance task on a rotating arena using two spatial flexibility task variants – reversal learning and set-shifting. To achieve this, we inactivated each of these structures in adult male Long-Evans rats by performing bilateral local muscimol (a GABAA receptor agonist) injections. A significantly disrupted performance was observed in reversal learning in the vHPC-inactivated, but not in the mPFC-inactivated rats. These results confirm the notion that the vHPC participates in some forms of behavioral flexibility, especially when spatial cues are needed. It seems, rather unexpectedly, that the mPFC is not taxed in these flexibility tasks on a rotating arena.
Trvalý link: http://hdl.handle.net/11104/0322152
Počet záznamů: 1