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Proteomics of mouse heart ventricles reveals mitochondria and metabolism as major targets of a post-infarction short-acting glp1ra-therapy

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    0545023 - ÚIACH 2022 RIV CH eng J - Článek v odborném periodiku
    Germano, J. F. - Sharma, A. - Šťastná, Miroslava - Huang, C. - Aniag, M. - Aceves, A. - Van Eyk, J.E. - Mentzer, R. M. - Piplani, H. - Andres, A. M. - Gottlieb, R. A.
    Proteomics of mouse heart ventricles reveals mitochondria and metabolism as major targets of a post-infarction short-acting glp1ra-therapy.
    International Journal of Molecular Sciences. Roč. 22, č. 16 (2021), č. článku 8711. E-ISSN 1422-0067
    Institucionální podpora: RVO:68081715
    Klíčová slova: glucagon-like peptide-1 receptor agonists (GLP1Ras) * proteomics * early cardiac remodeling
    Obor OECD: Analytical chemistry
    Impakt faktor: 6.208, rok: 2021
    Způsob publikování: Omezený přístup

    The global proteomics was employed to interrogate the target proteins, organelles and biological processes affected by short-acting GLP1Ra administered after permanent coronary artery ligation (PCAL).This approach showed a central role for mitochondria and mitochondria-associated metabolic pathways, such as fatty acid oxidation, in the beneficial effects of short-acting GLP1Ra on postinfarttion remodeling. The overexpression of proteins identified by protein-protein interaction networks, such as Atp2a2, may be important to the mechanism of action of GLP1Ra.
    Trvalý link: http://hdl.handle.net/11104/0321801

     
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