Počet záznamů: 1
Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment
- 1.0542909 - ÚFCH JH 2022 RIV GB eng J - Článek v odborném periodiku
Budimir, M. - Marković, Z. - Vajďák, J. - Jovanović, S. - Kubát, Pavel - Humpolíček, P. - Mičušik, M. - Danko, M. - Barras, A. - Milivojević, D. D. - Špitalsky, Z. - Boukherroub, R. - Marković, B. T.
Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment.
Radiation Physics and Chemistry. Roč. 185, AUG 2021 (2021), č. článku 109499. ISSN 0969-806X. E-ISSN 1879-0895
Institucionální podpora: RVO:61388955
Klíčová slova: Antibacterial photodynamic therapy * Carbon quantum dots * Gamma-irradiation * Polymer-matrix composite * Reactive oxygen species
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Obor OECD: Physical chemistry
Impakt faktor: 2.858, rok: 2020
Persistent microbial contamination of medical implant surfaces is becoming a serious threat to public health. This is principally due to antibiotic-resistant bacterial strains and the formation of bacterial biofilms. The development of novel antibacterial materials that will effectively fight both Gram-positive and Gram-negative bacteria and prevent biofilm formation represents a big challenge for researchers in the last few decades. In the present work, we report an antibacterial hydrophobic carbon quantum dots/polyurethane nanocomposite (hCQD-PU), with enhanced antibacterial properties induced by pre-treatment with gamma-irradiation. Hydrophobic quantum dots (hCQDs), which are capable of generating reactive oxygen species (ROS) upon irradiation with low-power blue light (470 nm), have been integrated into the polyurethane (PU) polymer matrix to form a photoactive nanocomposite. To modify its physical and chemical properties and improve its antibacterial efficacy, various doses of gamma irradiation (1, 10, and 200 kGy) in the air environment were applied to the formed nanocomposite. Gamma-irradiation pre-treatment significantly influenced the rise in ROS production, therefore, the prooxidative activity under the blue-light illumination of hCQD-PU was also significantly improved. The best antibacterial activity was demonstrated by the hCQD-PU nanocomposite irradiated with a dose of 200 kGy, with the complete eradication of Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 15 min of exposure to the blue lamp.
Trvalý link: http://hdl.handle.net/11104/0320242
Počet záznamů: 1