Počet záznamů: 1
Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: a road from failure to success in clinical applications
- 1.0537561 - FZÚ 2021 RIV NL eng J - Článek v odborném periodiku
Frtús, Adam - Smolková, Barbora - Uzhytchak, Mariia - Lunova, Mariia - Jirsa, M. - Kubinová, Šárka - Dejneka, Alexandr - Lunov, Oleg
Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: a road from failure to success in clinical applications.
Journal of Controlled Release. Roč. 328, Dec (2020), s. 59-77. ISSN 0168-3659. E-ISSN 1873-4995
Grant CEP: GA MŠk LTC19040
Institucionální podpora: RVO:68378271
Klíčová slova: iron oxide nanoparticles * endocytosis * magnetic resonance imaging * cytotoxicity * lysosomes * apoptosis * autophagy * cancer
Obor OECD: Biophysics
Impakt faktor: 9.776, rok: 2020
Způsob publikování: Omezený přístup
Iron oxide nanoparticles (IONPs) were the first generation of nanomaterials that reached real clinic use. Particularly, several IONPs-based magnetic resonance imaging contrast agents gained approval by US Food and Drug Administration (FDA). However, latter body of evidence revealed the overlooked side effects of IONPs, resulting in their withdrawal. Emerging evidence suggests that this happened due to poor understanding of the mechanisms by which IONPs act at the cellular and sub-cellular levels. Recent studies indicate that better understanding of fundamental signal modulations induced by nanomaterials is essential to overcome the clinical problems with nanoparticles. Therefore, in this article we critically review potential mechanisms of IONPs-cell interactions and challenges related with their identification.
Trvalý link: http://hdl.handle.net/11104/0315381
Počet záznamů: 1