Advanced-Model DCE-MRI regularized by ASL

0537062 - ÚPT 2021 GB eng A - Abstrakt
Jiřík, Radovan - Krátká, Lucie - Macíček, Ondřej - Souček, Karel - Dražanová, Eva - Fedr, Radek - Hampl, A. - Starčuk, Zenon
Advanced-Model DCE-MRI regularized by ASL.
Magnetic Resonance Materials in Physics, Biology and Medicine. Springer. Roč. 33, Suppl. 1 (2020), s. 171-172. ISSN 0968-5243. E-ISSN 1352-8661.
[ESMRMB 2020 Online, Annual Scientific Meeting /37./. 30.09.2020-02.10.2020, -]
Grant CEP: GA MŠMT(CZ) EF16_013/0001775; GA MŠMT(CZ) LM2018129
Institucionální podpora: RVO:68081731 ; RVO:68081707
Klíčová slova: DCE-MRI * ASL
Obor OECD: Medical laboratory technology (including laboratory samples analysis
https://link.springer.com/article/10.1007%2Fs10334-020-00873-1

Dynamic contrast-enhanced (DCE) MRI can provide maps of perfusion parameters useful for diagnostics and treatment monitoring, mainly in oncology. DCE-MRI with advanced pharmacokinetic (PK) models leads to a more complete set of estimated perfusion parameters (including blood flow, F, and permeabilitysurface area, PS), but it is less reliable, especially in estimates of F, mean capillary transit time, Tc, and extraction fraction, E, due to illconditioning, see Fig.1. We suggest to use additional information regularizing the DCE estimation process by combining it with arterialspin labeling (ASL).
Trvalý link: http://hdl.handle.net/11104/0314813