In Silico Study of the Effect of Humid air on Inhaled Aerosols in the Conducting Airways.

0507975 - ÚCHP 2020 SE eng C - Konferenční příspěvek (zahraniční konf.)
Stylianou, F. - Koullapis, P. - Velaga, S. - Ždímal, Vladimír - Kassinos, S.
In Silico Study of the Effect of Humid air on Inhaled Aerosols in the Conducting Airways.
EAC -Online program. -: Nordic Society for Aerosol Research, 2019, č. článku O1_A7_S02. ISBN N.
[European Aerosol Conference EAC 2019. Gothenburg (SE), 25.08.2019-30.08.2019]
Institucionální podpora: RVO:67985858
Klíčová slova: in silico study * hygroscopic growth effects * inhaled aerosol deposition
Obor OECD: Public and environmental health
https://www5.shocklogic.com/scripts/jmevent/programme.php?Client_Id=%27KONGRESS%27&Project_Id=%2719371%27&System_Id=1

Improving delivery efficiency of inhaled medications is of utmost importance, as it will lead to reduction of side effects associated with unwanted mouth-throat deposition, and reduction of treatment costs associated with decreased drug dosage. In addition, many next generation inhaled medications require precise targeting and dosing within the airways to be clinically acceptable, effective, and safe. In this direction, Longest et al. (2012) proposed the enhancement of drug particles with hygroscopic excipients. With appropriate selection of the initial size of the particles and the drug-excipient ratio, it is possible to achieve optimum drug delivery at targeted areas of the airways, by harnessing the natural high humidity environment of the airways. In this study, we evaluate the delivery efficiency of drug-excipient composites using high-fidelity numerical simulations.
Trvalý link: http://hdl.handle.net/11104/0298941