Targeting nanoparticles to modulate mTOR activity in cancer cells

0498007 - FZÚ 2019 GB eng A - Abstrakt
Lunova, M. - Prokhorov, Andriy - Jirsa, M. - Hof, Martin - Olžyńska, Agnieszka - Jurkiewicz, Piotr - Kubinová, Šárka - Lunov, Oleg - Dejneka, Alexandr
Targeting nanoparticles to modulate mTOR activity in cancer cells.
FEBS Open Bio. Wiley. Roč. 8, July (2018), s. 93-94. ISSN 2211-5463. E-ISSN 2211-5463
Grant CEP: GA MŠMT(CZ) LO1409; GA MŠMT(CZ) LM2015088
Institucionální podpora: RVO:68378271 ; RVO:61388955 ; RVO:68378041
Klíčová slova: mesoporous silica nanoparticles * iron-oxide nanoparticles * double-stranded-rna * drug-delivery
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.); Polymer science (UFCH-W); Biophysics (UEM-P)

Cancer is a major public health problem worldwide and is the second leading cause of death in the world. In recent years, there has been an unprecedented expansion in the field of nanomedicine with the development of new nanoparticles for the diagnosis and treatment of cancer. Yet, we still possess incomplete understanding of nano–bio interactions on ellular and molecular.levels. Such gap in the knowledge creates hurdles for clinical translation and commercialization of nanomedicines. Here we demonstrate that amino-functionalized polystyrene nanoparticles trigger cell death in hepatocellular carcinoma cells.
Trvalý link: http://hdl.handle.net/11104/0290433