Warburg effect—damping of electromagnetic oscillations

0483569 - FZÚ 2018 RIV US eng J - Článek v odborném periodiku
Pokorný, Jiří - Pokorný, Jan - Borodavka, Fedir
Warburg effect—damping of electromagnetic oscillations.
Electromagnetic Biology and Medicine. Roč. 36, č. 3 (2017), s. 270-278. ISSN 1536-8378. E-ISSN 1536-8386
Grant CEP: GA ČR GA16-12757S
Institucionální podpora: RVO:68378271
Klíčová slova: Warburg effect * mitochondrial dysfunction * water ordering * mitochondrial membrane potential * biological electromagnetic activity * cancer
Obor OECD: Biophysics
Impakt faktor: 1.360, rok: 2017

Mitochondrial dysfunction is a central defect in cells creating the Warburg and reverse Warburg effect cancers. Lowering of the inner membrane potential and shifting of the working point of mitochondria to high values of pH causes reorganization of the ordered water layer at the mitochondrial membrane. The reorganized ordered water layers at high pH values release electrons which are transferred to the cytosol rim of the layer. The electrons damp electromagnetic activity of Warburg effect cancer cells or fibroblasts associated with reverse Warburg effect cancer cells leading to lowered electromagnetic activity, disturbed coherence, increased oscillation frequencies and decreased level of biological functions. In reverse Warburg effect cancers, associated fibroblasts supply energy-rich metabolites to the cancer cell resulting in increased power of electromagnetic field, fluctuations due to shift of oscillations to an unstable nonlinear region, decreased frequency and loss of coherence.

Trvalý link: http://hdl.handle.net/11104/0278817