The chemical profile and pharmacodynamic properties of extracellular Wollea saccata biopolymer

0478834 - MBÚ 2018 RIV NL eng J - Článek v odborném periodiku
Šutovská, M. - Kočmálová, M. - Pappová, L. - Fraňová, S. - Chyba, A. - Kopecký, Jiří - Lukavský, Jaromír - Cepák, Vladislav - Capek, P.
The chemical profile and pharmacodynamic properties of extracellular Wollea saccata biopolymer.
International Journal of Biological Macromolecules. Roč. 103, OCT 2017 (2017), s. 863-869. ISSN 0141-8130. E-ISSN 1879-0003
Grant CEP: GA TA ČR TE01020080
Institucionální podpora: RVO:61388971 ; RVO:67985939
Klíčová slova: Wollea saccata * Extracellular proteoglycan * Pharmacodynamic properties
Obor OECD: Microbiology; Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials (BU-J)
Impakt faktor: 3.909, rok: 2017

Microalgae organisms are of interest for many biotechnology applications due to the production of a wide range of biologically active compounds. Incubation of Wollea saccata in a large scale afforded a mucilaginous, high molecular weight biopolymer composed of carbohydrate, protein and phenolic compounds. Sugar moiety was rich in hexoses (60%) and 6-deoxyhexoses (31%), while only 9% of pentoses was identified. Methylation analysis revealed about 40 types of methylated sugar derivatives, suggesting a very complex structure of Wollea biopolymer. Pharmacological studies revealed new pharmacodynamic properties of cyanobacteria biopolymer, i.e. antitussive and bronchodilatory. Biopolymer was able to suppress the cough reflex induced by chemical tussigen, but its effect was lower than that of codeine, the strongest antitussive agent. The bronchodilatory effect was similar or higher than the effect of salbutamol, a bronchodilatory drug used in a clinical practice. In pharmacological studies, there were no signs of toxicity or side effects in the animals following administration of Wollea biopolymer.
Trvalý link: http://hdl.handle.net/11104/0274884