Photodynamic effects of 31 different phthalocyanines on a human keratinocyte cell line

0398140 - BÚ 2014 RIV GB eng J - Článek v odborném periodiku
Jančula, Daniel - Maršálek, Blahoslav - Babica, Pavel
Photodynamic effects of 31 different phthalocyanines on a human keratinocyte cell line.
Chemosphere. Roč. 93, č. 6 (2013), s. 870-874. ISSN 0045-6535. E-ISSN 1879-1298
Grant CEP: GA TA ČR TA01010356
Grant ostatní: European Commission(XE) FP/2007-2013 no.2SGA2858
Program: FP/2007-2013
Institucionální podpora: RVO:67985939
Klíčová slova: phthalocyanines * photodynamics * toxicity
Kód oboru RIV: EF - Botanika
Impakt faktor: 3.499, rok: 2013

We have found light dependent toxicity of different groups of Pcs on HaCaT cells. The most pronounced toxicity was elicited by Pcs with high positive densities at peripheral parts of substituent groups under illumination by white light. EC50 values for HaCaT cells are an order or two orders of magnitude higher than concentrations considered for management purposes in aquaculture, which indicate the safety of such applications for human or animal skin cells after the exposition. Nevertheless, more research including risk assessment should be done to confirm such conclusions.
Trvalý link: http://hdl.handle.net/11104/0225677