Sequential Shh expression in the development of the mouse upper functional incisor

0397915 - ÚEM 2014 RIV US eng J - Článek v odborném periodiku
Hovořáková, Mária - Smrčková, Lucie - Lesot, H. - Lochovská, Kateřina - Peterka, Miroslav - Peterková, Renata
Sequential Shh expression in the development of the mouse upper functional incisor.
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Additional Title Information. Roč. 320, č. 7 (2013), s. 455-464. ISSN 1552-5007. E-ISSN 1552-5015
Grant CEP: GA ČR GA304/09/1579; GA ČR(CZ) GAP305/12/1766
Institucionální podpora: RVO:68378041
Klíčová slova: mouse * craniofacial * ED13.5
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.876, rok: 2013

This study brings new insights into the early development of the upper incisor in mice and completes the data on normal mouse incisor development. The temporal-spatial pattern of Shh expression reflects the development of two tooth generations, being detectable in two successive, antero-posteriorly located areas in the prospective incisor region in the upper jaw. The first, anterior and superficial Shh expression domain reflects the rudimentary tooth development suppressed during evolution. Only the subsequent, posterior and deeper Shh expression region, appearing at ED13.5, correlates with the prospective upper functional incisor in wild-type mice.
Trvalý link: http://hdl.handle.net/11104/0225536