Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use

0380690 - ÚEB 2013 RIV eng P - Patentový dokument
Moravcová, Daniela - Havlíček, Libor - Kryštof, Vladimír - Lenobel, René - Binarová, Pavla - Mlejnek, P. - Vojtěšek, B. - Uldrijan, S. - Schmülling, T. - Strnad, Miroslav
Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use.
2012. Vlastník: Ústav experimentální botaniky AV ČR, v. v. i - Univerzita Palackého v Olomouci. Datum udělení patentu: 13.03.2012. Číslo patentu: CA2524344
Výzkumný záměr: CEZ:AV0Z50380511
Klíčová slova: Pyrazolo[4,3-D]pyrimidines * preparation * methods of use
Kód oboru RIV: CE - Biochemie
http://brevets-patents.ic.gc.ca/opic-cipo/cpd/eng/patent/2524344/summary.html

The invention relates to 3-, 7-disubstituted pyrazolo[4,3-d]pyrimidines represented by the general formula I (I), and pharmaceutically acceptable salts thereof, wherein R3 is selected from the group consisting of alkyl, cycloalkyl, , cycloalkyl alkyl, cycloheteroalkyl alkyl, cycloheteroalkyl, aryl, heterocycle, heteroaryl, arylalkyl, heteroarylalkyl, and heteroalkyl, wherein each of the groups may optionally be substituted, R7 is selected from the group consisting of halogen, hydroxyl, hydroxylamino, amino, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, unsubstituted or substituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroarylakyl, substituted or unsubstituted cycloalkyl alkyl, substituted or unsubstituted cycloheteroalkyl alkyl; R7'-X- wherein X is an - NH-, -N(alkyl)-, -0- or -S- moiety and R7' is selected from the group consisting of H, alkyl, cycloalkyl, aryl, alkylcycloalkyl, arylalkyl, heterocycle, heterocyclealkyl, substituted alkyl, substituted cycloalkyl, substituted aryl, substituted arylalkyl, substituted heterocycle, substituted heteroaryl, substituted heteroarylalkyl, substituted heteroalkyl, substituted cycloalkyl alkyl and substituted cycloheteroalkyl alkyl, wherein the groups are preferably substituted by more than one halogen, hydroxyl, amino, mercapto, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, alkyl, alkoxy, and substituted alkyl group.
Trvalý link: http://hdl.handle.net/11104/0211333