Počet záznamů: 1
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy
- 1.0345886 - ÚOCHB 2011 RIV NL eng J - Článek v odborném periodiku
Keough, D. T. - Hocková, Dana - Krečmerová, Marcela - Česnek, Michal - Holý, Antonín - Naesens, L. - Brereton, I. M. - Winzor, D. J. - de Jersey, J. - Guddat, L. W.
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy.
Molecular and Biochemical Parasitology. Roč. 173, č. 2 (2010), s. 165-169. ISSN 0166-6851. E-ISSN 1872-9428
Grant CEP: GA MŠMT 1M0508
Grant ostatní: National Health and Medical Research Council(AU) 569703
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: acyclic nucleoside phosphonates * Plasmodium vivax * 6-oxopurine phosphoribosyltransferase
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 2.875, rok: 2010
For protozoan parasites, 6-oxopurine phosphoribosyltransferases (PRTases) provide the only metabolic pathway to synthesize the purine nucleoside monophosphates essential for DNA/RNA production. This enzyme from Plasmodium vivax was cloned, expressed and purified and its properties compared with those of the corresponding enzymes from human and P. falciparum. Several acyclic nucleoside phosphonates were evaluated as inhibitors of PvHGPRT giving Ki values as low as 0.5 .mu.M.
Trvalý link: http://hdl.handle.net/11104/0187064
Počet záznamů: 1