Počet záznamů: 1
Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study
- 1.0343468 - ÚI 2011 RIV US eng J - Článek v odborném periodiku
Vrajová, M. - Šťastný, František - Horáček, J. - Lochman, J. - Šerý, O. - Peková, S. - Klaschka, Jan - Höschl, C.
Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study.
Neurochemical Research. Roč. 35, č. 7 (2010), s. 994-1002. ISSN 0364-3190. E-ISSN 1573-6903
Grant ostatní: GA MZd(CZ) NR9324
Výzkumný záměr: CEZ:AV0Z50110509; CEZ:AV0Z10300504
Klíčová slova: schizophrenia * hippocampus * GluN1 subunit of NMDA receptor * splice variants * laterality
Kód oboru RIV: FL - Psychiatrie, sexuologie
Impakt faktor: 2.608, rok: 2010
There is accumulating evidence that disturbances in N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (eight isoforms altogether) as well as the mRNA individual isoforms in the postmortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. Our results suggest that NMDA-R hypofunction in schizophrenia might be selectively dependent on the dysregulation of GluN1 subunit expression, which exhibits a somewhat different expression in the left/right hippocampus of psychotic patients.
Trvalý link: http://hdl.handle.net/11104/0185943
Počet záznamů: 1