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New coupling strategy for radionuclide labeling of synthetic polymers
- 1.0342352 - ÚMCH 2011 RIV GB eng J - Článek v odborném periodiku
Hrubý, Martin - Kučka, Jan - Nováková, Michaela - Macková, Hana - Vetrík, Miroslav
New coupling strategy for radionuclide labeling of synthetic polymers.
Applied Radiation and Isotopes. Roč. 68, č. 2 (2010), s. 334-339. ISSN 0969-8043. E-ISSN 1872-9800
Grant CEP: GA AV ČR KAN200200651; GA ČR GA202/09/2078; GA MŠMT 1M0505
Výzkumný záměr: CEZ:AV0Z40500505
Klíčová slova: polymer * radionuclide * labeling
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Impakt faktor: 0.999, rok: 2010
We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven.
Trvalý link: http://hdl.handle.net/11104/0005864
Počet záznamů: 1