Počet záznamů: 1
Changes of parvalbumin expression in the spinal cord after peripheral inflammation
- 1.0328959 - FGÚ 2010 RIV CZ eng J - Článek v odborném periodiku
Zachařová, Gisela - Sojka, David - Paleček, Jiří
Changes of parvalbumin expression in the spinal cord after peripheral inflammation.
Physiological Research. Roč. 58, č. 3 (2009), s. 435-442. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GA305/06/1115; GA ČR(CZ) GA304/08/0256; GA MŠMT(CZ) LC554
Grant ostatní: EC(XE) LSH-CT-2004-511978
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: pain * parvalbumin * spinal cord * GABA
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 1.430, rok: 2009
Parvalbumin (PV) is a calcium-binding protein that is expressed by numerous neuronal subpopulations in the central nervous system.There was a significant reduction of PV immunoreactivity in the superficial dorsal horn region ipsilateral to the arthritis after induction of the peripheral inflammation. The ipsilateral area and intensity of PV staining in this area were reduced to 38 % and 37 %, respectively, out of the total PV staining on both sides. It is suggested that this reduction may reflect decreased expression of PV in GABAergic inhibitory neurons. Reduction of PV concentration in the presynaptic GABAergic terminals could lead to potentiation of inhibitory transmission in the spinal cord. Our results suggest that changes in expression of calcium-binding proteins in spinal cord dorsal horn neurons may modulate nociceptive transmission
Trvalý link: http://hdl.handle.net/11104/0175129
Počet záznamů: 1