Cytokinin response factors regulate PIN-FORMED auxin transporters

0454259 - ÚEB 2016 RIV GB eng J - Článek v odborném periodiku
Šimášková, M. - O'Brien, J.A. - Khan, M. - Van Noorden, G. - Ötvös, K. - Vieten, A. - De Clercq, E. - Van Haperen, J.M.A. - Cuesta, C. - Hoyerová, Klára - Vanneste, S. - Marhavý, P. - Wabnik, K. - Van Breusegem, F. - Nowack, M. - Murphy, A. - Friml, J. - Weijers, D. - Beeckman, T. - Benková, E.
Cytokinin response factors regulate PIN-FORMED auxin transporters.
Nature Communications. Roč. 6, NOV (2015), s. 8717. E-ISSN 2041-1723
Institucionální podpora: RVO:61389030
Klíčová slova: ARABIDOPSIS-THALIANA * ROOT-MERISTEM * TRANSCRIPTION FACTORS
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 11.329, rok: 2015

Auxin and cytokinin are key endogenous regulators of plant development. Although cytokinin-mediated modulation of auxin distribution is a developmentally crucial hormonal interaction, its molecular basis is largely unknown. Here we show a direct regulatory link between cytokinin signalling and the auxin transport machinery uncovering a mechanistic framework for cytokinin-auxin cross-talk. We show that the CYTOKININ RESPONSE FACTORS (CRFs), transcription factors downstream of cytokinin perception, transcriptionally control genes encoding PIN-FORMED (PIN) auxin transporters at a specific PIN CYTOKININ RESPONSE ELEMENT (PCRE) domain. Removal of this cis-regulatory element effectively uncouples PIN transcription from the CRF-mediated cytokinin regulation and attenuates plant cytokinin sensitivity. We propose that CRFs represent a missing cross-talk component that fine-tunes auxin transport capacity downstream of cytokinin signalling to control plant development.
Trvalý link: http://hdl.handle.net/11104/0254988