Copper-mediated Synthesis of Mono- and Dichlorinated Diaryl Ethers

0429530 - ÚCHP 2015 RIV GB eng J - Článek v odborném periodiku
Čermák, Jan K. - Církva, Vladimír
Copper-mediated Synthesis of Mono- and Dichlorinated Diaryl Ethers.
Tetrahedron Letters. Roč. 55, č. 30 (2014), s. 4185-4188. ISSN 0040-4039. E-ISSN 1873-3581
Institucionální podpora: RVO:67985858
Klíčová slova: O-arylation * Chan-Lam coupling * kovats indices
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 2.379, rok: 2014

An efficient synthesis of polychlorinated diphenyl ethers (PCDEs) using the Cu(OAc)2 catalyzed Chan–Lam coupling reaction is described. A library of all possible mono- and dichlorinated diphenyl ether congeners was prepared and characterized using MS, 1H, and 13C NMR spectroscopy, and Kovats retention indices. Our approach, using the optimized reaction conditions (i.e., reaction temperature, oxidizing atmosphere and base), significantly improves and simplifies the process compared to previously reported syntheses.
Trvalý link: http://hdl.handle.net/11104/0235307