Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

0399579 - ÚEB 2014 RIV GB eng J - Článek v odborném periodiku
Dvořáková, Marcela - Nencka, Radim - Dejmek, Milan - Zborníková, Eva - Březinová, Anna - Přibylová, Marie - Pohl, Radek - Migaud, M. E. - Vaněk, Tomáš
Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose.
Organic & Biomolecular Chemistry. Roč. 11, č. 34 (2013), s. 5702-5713. ISSN 1477-0520. E-ISSN 1477-0539
Institucionální podpora: RVO:61389030 ; RVO:61388963
Klíčová slova: DEACETYLASES * FURANOSIDES * METABOLITE
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 3.487, rok: 2013

The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.
Trvalý link: http://hdl.handle.net/11104/0226914