Amides derived from heteroaromatic amines and selected steryl hemiesters

0398419 - ÚEB 2014 RIV US eng J - Článek v odborném periodiku
Bildziukevich, Uladzimir - Rárová, L. - Šaman, David - Havlíček, Libor - Drašar, P. - Wimmer, Zdeněk
Amides derived from heteroaromatic amines and selected steryl hemiesters.
Steroids. Roč. 78, č. 14 (2013), s. 1347-1352. ISSN 0039-128X. E-ISSN 1878-5867
Grant CEP: GA ČR(CZ) GAP503/11/0616
Grant ostatní: GA MŠk(CZ) ED0007/01/01
Program: ED
Institucionální podpora: RVO:61389030 ; RVO:61388963
Klíčová slova: Heteroaromatic amine * Cholesterol * Lanosterol
Kód oboru RIV: FR - Farmakologie a lékárnická chemie
Impakt faktor: 2.716, rok: 2013

The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and heteroaromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-lymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3–5 and 7–10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-lymphoblastic leukemia cell line.
Trvalý link: http://hdl.handle.net/11104/0225925