Počet záznamů: 1
Multiple Cholinergic Signaling Pathways in Pituitary Gonadotrophs
- 1.0392526 - FGÚ 2014 RIV US eng J - Článek v odborném periodiku
Zemková, Hana - Kučka, M. - Bjelobaba, I. - Tomic, M. - Stojilkovic, S. S.
Multiple Cholinergic Signaling Pathways in Pituitary Gonadotrophs.
Endocrinology. Roč. 154, č. 1 (2013), s. 421-433. ISSN 0013-7227. E-ISSN 1945-7170
Grant CEP: GA ČR(CZ) GBP304/12/G069; GA AV ČR(CZ) IAA500110910
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: acetylcholine * nicotinic receptor channels * muscarinic receptors * calcium * cAMP * inward currents * SK channels * GnRH
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 4.644, rok: 2013
Multiple cholinergic receptors are expressed in gonadotrophs. Activation of nicotinic channels by ACh is capable of generating an inward current, facilitation of electrical activity and Ca2+ influx, M3 receptor-mediated, phospholipase C-dependent Ca2+ mobilization activates an outward apamin-sensitive K+ current and causes hyperpolarization. The activation of M4 receptors by ACh inhibited cAMP production and GnRH-induced LH release
Trvalý link: http://hdl.handle.net/11104/0221365
Počet záznamů: 1