0165928 - UCHP-M 20000143 RIV NL eng J - Článek v odborném periodiku
Lescrinier, E. - Esnouf, R. - Schraml, Jan - Busson, R. - Heus, H. A. - Hilbers, C. W. - Herdewijn, P.
Solution Structure of a HNA-RNA Hybrid.
Chemistry & Biology. Roč. 7, č. 9 (2000), s. 719-731. ISSN 1074-5521. E-ISSN 1879-1301
Výzkumný záměr: CEZ:AV0Z4072921
Kód oboru RIV: CI - Průmyslová chemie a chemické inženýrství
Impakt faktor: 5.717, rok: 2000

The P-P distance across the minor groove, which is close to A-form, and the rigid conformation of the HNA-RNA com plex, explain its resistance towards degradation by Rnase H. The A-form character of the HNA-RNA duplex and the reduced flexibility of the HNA strand is possibly responsible for the stereoselectivity of HNA templates in non-enzymatic replication of oligonucleotides, supporting the theory that nucleosides with six-membered rings could have existed at some stage in molecular evolution.
Trvalý link: http://hdl.handle.net/11104/0063080