0598405 - FGÚ 2025 RIV CZ eng J - Článek v odborném periodiku
Bardová, Kristina - Janovská, Petra - Vávrová, Anna - Kopecký, Jan - Zouhar, Petr
Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather than Brown Fat Could Counteract Obesity.
Physiological Research. Roč. 73, Suppl.1 (2024), S279-S294. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MŠMT(CZ) LX22NPO5104; GA ČR(CZ) GA22-07004S
Institucionální podpora: RVO:67985823
Klíčová slova: regulation of thermogenesis * warm-blooded animals * body temperature * UCP1
Obor OECD: Endocrinology and metabolism (including diabetes, hormones)
Impakt faktor: 1.9, rok: 2023 ; AIS: 0.394, rok: 2023
Způsob publikování: Open access
Web výsledku:
https://www.biomed.cas.cz/physiolres/pdf/2024/73_S279.pdf

DOI: https://doi.org/10.33549/physiolres.935361

Warm-blooded animals such as birds and mammals are able to protect stable body temperature due to various thermogenic mechanisms. These processes can be facultative (occurring only under specific conditions, such as acute cold) and adaptive (adjusting their capacity according to long-term needs). They can represent a substantial part of overall energy expenditure and, therefore, affect energy balance. Classical mechanisms of facultative thermogenesis include shivering of skeletal muscles and (in mammals) non-shivering thermogenesis (NST) in brown adipose tissue (BAT), which depends on uncoupling protein 1 (UCP1). Existence of several alternative thermogenic mechanisms has been suggested. However, their relative contribution to overall heat production and the extent to which they are adaptive and facultative still needs to be better defined. Here we focus on comparison of NST in BAT with thermogenesis in skeletal muscles, including shivering and NST. We present indications that muscle NST may be adaptive but not facultative, unlike UCP1-dependent NST. Due to its slow regulation and low energy efficiency, reflecting in part the anatomical location, induction of muscle NST may counteract development of obesity more effectively than UCP1-dependent thermogenesis in BAT.
Trvalý link: https://hdl.handle.net/11104/0356071