0598033 - FGÚ 2025 RIV CZ eng J - Článek v odborném periodiku
Benák, Daniel - Kolář, František - Hlaváčková, Markéta
Epitranscriptomic Regulations in the Heart.
Physiological Research. Roč. 73, Suppl.1 (2024), S185-S198. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MŠMT(CZ) LX22NPO5104; GA ČR(CZ) GA24-10497S
Institucionální podpora: RVO:67985823
Klíčová slova: epitranscriptomics * RNA modifications * m6 A * RNA * heart
Obor OECD: Cardiac and Cardiovascular systems
Impakt faktor: 1.9, rok: 2023 ; AIS: 0.393, rok: 2023
Způsob publikování: Open access
Web výsledku:
https://www.biomed.cas.cz/physiolres/pdf/2024/73_S185.pdf

DOI: https://doi.org/10.33549/physiolres.935265

RNA modifications affect key stages of the RNA life cycle, including splicing, export, decay, and translation. Epitranscriptomic regulations therefore significantly influence cellular physiology and pathophysiology. Here, we selected some of the most abundant modifications and reviewed their roles in the heart and in cardiovascular diseases: N6 -methyladenosine (m6 A), N6 ,2‘-O-dimethyladenosine (m6 Am), N1 -methyladenosine (m1 A), pseudouridine (Ψ), 5-methylcytidine (m5 C), and inosine (I). Dysregulation of epitranscriptomic machinery affecting these modifications vastly changes the cardiac phenotype and is linked with many cardiovascular diseases such as myocardial infarction, cardiomyopathies, or heart failure. Thus, a deeper understanding of these epitranscriptomic changes and their regulatory mechanisms can enhance our knowledge of the molecular underpinnings of prevalent cardiac diseases, potentially paving the way for novel therapeutic strategies.
Trvalý link: https://hdl.handle.net/11104/0355808