Synthesis of Fluorinated Methyl β-Lactosides

0586569 - ÚCHP 2025 CZ eng K - Konferenční příspěvek (tuzemská konf.)
Krčil, Aleš
Synthesis of Fluorinated Methyl β-Lactosides.
Proceedings of Abstracts. Prague: Institute of Chemical Process Fundamentals of the CAS, v. v. i., 2024 - (Orvalho, S.; Wagner, Z.), s. 23-24. ISBN 978-80-86186-32-0.
[Bažant Postgraduate Conference 2024. Prague (CZ), 05.06.2024-06.06.2024]
Grant CEP: GA ČR(CZ) GA23-05146S
Institucionální podpora: RVO:67985858
Klíčová slova: flurinated carbohydrates * galectin * deoxyfluorination
Obor OECD: Organic chemistry

In my contribution, I will describe the synthesis of a complete series of mono-deoxyfluorinated methyl β-lactosides (1–7). Their affinity towards hgals will be determined by analytical method ELISA. The synthesis relies on monosaccharide building blocks, which serves as key intermediates that are transformed into the target products through glycosylation followed by final deprotection steps.
Trvalý link: https://hdl.handle.net/11104/0354030