Počet záznamů: 1  

Influence of the gut microbiome on appetite-regulating neuropeptides in the hypothalamus: Insight from conventional, antibiotic-treated, and germ-free mouse models of anorexia nervosa

  1. 1.
    0585588 - MBÚ 2025 RIV NL eng J - Článek v odborném periodiku
    Roubalová, Radka - Procházková, Petra - Kovářová, Tereza - Ježková, Janet - Hrnčíř, Tomáš - Tlaskalová-Hogenová, Helena - Papežová, H.
    Influence of the gut microbiome on appetite-regulating neuropeptides in the hypothalamus: Insight from conventional, antibiotic-treated, and germ-free mouse models of anorexia nervosa.
    Neurobiology of Disease. Roč. 193, April 2024 (2024), č. článku 106460. ISSN 0969-9961. E-ISSN 1095-953X
    Grant CEP: GA MZd(CZ) NU22-04-00010
    Institucionální podpora: RVO:61388971
    Klíčová slova: Microbiome * Eating disorders * Activity-based anorexia model * Appetite regulation * Neuropeptide Y * Gut barrier
    Obor OECD: Microbiology
    Impakt faktor: 6.1, rok: 2022
    Způsob publikování: Open access
    https://www.sciencedirect.com/science/article/pii/S0969996124000597?via%3Dihub

    Recent research highlights the profound impact of the gut microbiome on neuropsychiatric disorders, shedding light on its potential role in shaping human behavior. In this study, we investigate the role of the gut microbiome in appetite regulation using activity-based anorexia (ABA) mouse model of anorexia nervosa (AN) a severe eating disorder with significant health consequences. ABA was induced in conventional, antibiotic-treated, and germ-free mice. Our results show the clear influence of the gut microbiome on the expression of four orexigenic (neuropeptide Y, agouti-related peptide, melanin-concentrating hormone, and orexin) and four anorexigenic peptides (cocaine- and amphetamine-regulated transcript, corticotropin-releasing hormone, thyrotropinreleasing hormone, and pro-opiomelanocortin) in the hypothalamus. Additionally, we assessed alterations in gut barrier permeability. While variations were noted in germ-free mice based on feeding and activity, they were not directly attributable to the gut microbiome. This research emphasizes that the gut microbiome is a pivotal factor in AN's appetite regulation beyond just dietary habits or physical activity.
    Trvalý link: https://hdl.handle.net/11104/0353368

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.