Počet záznamů: 1
Metabolomic Analysis of Microcystis aeruginosa After Exposure to the Algicide L-Lysine
- 1.0584265 - BC 2024 RIV DE eng J - Článek v odborném periodiku
Yan, X. - Zhao, F. - Wang, G. - Wang, Z. - Zhou, Ming-Xi - Zhang, L. - Wang, G. - Chen, Y.
Metabolomic Analysis of Microcystis aeruginosa After Exposure to the Algicide L-Lysine.
Bulletin of Environmental Contamination and Toxicology. Roč. 110, č. 1 (2023), č. článku 12. ISSN 0007-4861. E-ISSN 1432-0800
Institucionální podpora: RVO:60077344
Klíčová slova: L-lysine * Microcystis aeruginosa * Microcystin * Metabolomic analysis * Arginine metabolism * Ornithine-ammonia cycle
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 2.7, rok: 2023
Způsob publikování: Omezený přístup
https://link.springer.com/article/10.1007/s00128-022-03658-5
The widespread occurrence of cyanobacteria blooms damages the water ecosystem and threatens the safety of potable water and human health. Exogenous L-lysine significantly inhibits the growth of a dominant cyanobacteria Microcystis aeruginosa in freshwater. However, the molecular mechanism of how lysine inhibits the growth of M. aeruginosa is unclear. In this study, both non-target and target metabolomic analysis were performed to investigate the effects of algicide L-lysine. The results showed that 8 mg L- 1 lysine most likely disrupts the metabolism of amino acids, especially the arginine and proline metabolism. According to targeted amino acid metabolomics analysis, only 3 amino acids (L-arginine, ornithine, and citrulline), which belong to the ornithine-ammonia cycle (OAC) in arginine metabolic pathway, showed elevated levels. The intracellular concentrations of ornithine, citrulline, and arginine increased by 115%, 124%, and 19.4%, respectively. These results indicate that L-lysine may affect arginine metabolism and OAC to inhibit the growth of M. aeruginosa.
Trvalý link: https://hdl.handle.net/11104/0352340
Počet záznamů: 1