Assembly of the 81.6 Mb centromere of pea chromosome 6 elucidates the structure and evolution of metapolycentric chromosomes

0584246 - BC 2024 RIV US eng J - Článek v odborném periodiku
Macas, Jiří - Robledillo, Laura Avila - Kreplak, J. - Novák, Petr - Koblížková, Andrea - Vrbová, Iva - Burstin, J. - Neumann, Pavel
Assembly of the 81.6 Mb centromere of pea chromosome 6 elucidates the structure and evolution of metapolycentric chromosomes.
PLoS Genetics. Roč. 19, č. 2 (2023), č. článku e1010633. ISSN 1553-7404. E-ISSN 1553-7404
Grant CEP: GA MŠMT(CZ) LM2018131
Institucionální podpora: RVO:60077344
Klíčová slova: genome * kinetochore * duplication * annotation * generation * alignment * sequence * provides * shows * gene
Obor OECD: Genetics and heredity (medical genetics to be 3)
Impakt faktor: 4.5, rok: 2022
Způsob publikování: Open access
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010633

Author summaryDespite their conserved function, centromeres exhibit considerable variation in their morphology and sequence composition. For example, centromere activity is restricted to a single region in monocentric chromosomes, but is distributed along the entire chromosome length in holocentric chromosomes. The principles of centromere evolution that led to this variation are largely unknown, partly due to the lack of high-quality centromere assemblies. Here, we present an assembly of the pea metapolycentromere, a unique type of centromere that represents an intermediate stage between monocentric and holocentric organizations. This study not only provides a detailed insight into sequence organization, but also reveals possible mechanisms for the formation of the metapolycentromere through the spread of centromeric chromatin and the accumulation of satellite DNA.
Trvalý link: https://hdl.handle.net/11104/0352322