Development of spray-dried powder hand sanitiser with prolonged effectivity.

0583944 - ÚOCHB 2025 RIV US eng J - Článek v odborném periodiku
Večerková, L. - Mašková, L. - Knejzlík, Zdeněk - Kašpar, O. - Tokárová, V.
Development of spray-dried powder hand sanitiser with prolonged effectivity.
Scientific Reports. Roč. 14, February (2024), č. článku 4827. ISSN 2045-2322. E-ISSN 2045-2322
Institucionální podpora: RVO:61388963
Klíčová slova: chlorhexidine * ingredients * efficacy
Impakt faktor: 4.6, rok: 2022
Způsob publikování: Open access
https://doi.org/10.1038/s41598-024-55503-w

Since the outbreak of the COVID-19 pandemic, the use of hand sanitisers has become an inseparable part of our personal hygiene. However, the short-term effect and the need for frequent application are shortcomings that impair the overall protection. Another aspect is that repeated use of some products (typically alcohol-based) may cause skin irritation or eventually more severe health problems. This work proposes spray-drying as a suitable method for the preparation of swellable chitosan carriers, allowing for encapsulation and sustained release of antibacterial chlorhexidine digluconate as a model active substance. After application to hands, micron-sized particles preferentially accommodate space between epidermal ridges, protected against attrition. Thanks to their small size (d<10m), particles are comfortable to carry since they are not recognisable by somatosensory receptors. The performance of formulations with various amounts of chlorhexidine and cross-linker was tested and compared with selected commercial disinfectants available on the Czech market (ethanol gel and alcoholic solution with chlorhexidine) against E. coli and S. epidermidis. The real-life performance was investigated with twelve volunteers performing various activities for up to 2h. Finally, a replica of the human index finger with accurately captured micro-topology was proposed and compared with volunteers' fingers concerning the total amount of adhered and detached particles.
Trvalý link: https://hdl.handle.net/11104/0351932