Telomerase RNA gene paralogs in plants the usual pathway to unusual telomeres

0583724 - BFÚ 2024 RIV GB eng J - Článek v odborném periodiku
Zavodnik, M. - Fajkus, Petr - Franek, M. - Kopecký, David - Garcia, S. - Dodsworth, S. - Orejuela, A. - Kilar, A. - Ptáček, J. - Mátl, Martin - Hyskova, A. - Fajkus, Jiří - Peška, Vratislav
Telomerase RNA gene paralogs in plants the usual pathway to unusual telomeres.
New Phytologist. Roč. 239, č. 6 (2023), s. 2353-2366. ISSN 0028-646X. E-ISSN 1469-8137
Grant CEP: GA ČR(CZ) GA23-06643S; GA ČR(CZ) GX20-01331X
Institucionální podpora: RVO:68081707 ; RVO:61389030
Klíčová slova: syntenic regions * evolution * centromere * diversity * evolution * land plants * mechanism of telomere transitions * telomerase RNA paralogs * unusual telomere DNA
Obor OECD: Plant sciences, botany; Plant sciences, botany (UEB-Q)
Impakt faktor: 9.4, rok: 2022
Způsob publikování: Open access
https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.19110

Telomerase, telomeric DNA and associated proteins together represent a complex, finely tuned and functionally conserved mechanism that ensures genome integrity by protecting and maintaining chromosome ends. Changes in its components can threaten an organism's viability. Nevertheless, molecular innovation in telomere maintenance has occurred multiple times during eukaryote evolution, giving rise to species/taxa with unusual telomeric DNA sequences, telomerase components or telomerase-independent telomere maintenance. The central component of telomere maintenance machinery is telomerase RNA (TR) as it templates telomere DNA synthesis, its mutation can change telomere DNA and disrupt its recognition by telomere proteins, thereby leading to collapse of their end-protective and telomerase recruitment functions.
Trvalý link: https://hdl.handle.net/11104/0351722