Epitranscriptomic regulatory mechanisms, cardiomyocyte physiology, and nonconventional cardioprotective interventions

0583496 - FGÚ 2024 RIV US eng A - Abstrakt
Hlaváčková, Markéta - Benák, Daniel - Sotáková-Kašparová, Dita - Holzerová, Kristýna - Hrdlička, Jaroslav - Telenský, P. - Šimonová, Anna - Cahová, Hana - Pecinová, Alena - Eckhardt, Adam - Olsen, M. - Kobets, Tetyana - Neckář, Jan - Kolář, František
Epitranscriptomic regulatory mechanisms, cardiomyocyte physiology, and nonconventional cardioprotective interventions.
European Journal of Clinical Investigation. Wiley. Roč. 53, Suppl.1 (2023), č. článku 57ASM-142. ISSN 0014-2972. E-ISSN 1365-2362.
[ANNUAL SCIENTIFIC MEETING /57./. 07.06.2023-09.06.2023, Praha]
Grant CEP: GA MŠMT(CZ) LX22NPO5104
Institucionální podpora: RVO:67985823 ; RVO:61388963
Klíčová slova: ischemic heart disease * ischemia * epitranscriptomics
Obor OECD: Cardiac and Cardiovascular systems
https://onlinelibrary.wiley.com/doi/10.1111/eci.13992

Our study indicate that maternal diabetes and Hif1a deficiency have combinatorial effects on the development of the cardiac sympathetic nervous system. Consequently, HIF1a dysregulation may contribute to various sympathetic abnormalities underlying cardiac pathologies, including heart failure and sudden cardiac death. These findings highlight the importance of consid-ering maternal health and genetic factors in the develop-ment of adverse cardiac outcomes in offspring.
Trvalý link: https://hdl.handle.net/11104/0351461