Cardiac cachexia is associated with altered expression of genes related to iron and lipid metabolism

0583471 - FGÚ 2024 RIV US eng A - Abstrakt
Janovská, Petra - Kobets, Tetyana - Kuda, Ondřej - Steiner Mrázová, Lenka - Stránecký, V. - Melenovský, V. - Kopecký, Jan
Cardiac cachexia is associated with altered expression of genes related to iron and lipid metabolism.
European Journal of Clinical Investigation. Wiley. Roč. 53, Suppl.1 (2023), č. článku 57ASM-139. ISSN 0014-2972. E-ISSN 1365-2362.
[ANNUAL SCIENTIFIC MEETING /57./. 07.06.2023-09.06.2023, Praha]
Grant CEP: GA MŠMT(CZ) LX22NPO5104
Institucionální podpora: RVO:67985823
Klíčová slova: heart failure * adipose tissue * cardiac cachexia
Obor OECD: Cardiac and Cardiovascular systems
https://onlinelibrary.wiley.com/doi/10.1111/eci.13992

Deeper lipidomic analysis in EAT uncovered potential higher oxidation of polyunsaturated lipids in cachexia. Analysis of significantly regulated phosphatidyl ethanolmanines revealed higher content of arachidonic acid at sn2 position. Changes in iron and lipid metabolism in both EAT and MYO can be key markers of cardiac cachexia, they are more pronounced in EAT, and suggest the role of EAT-MYO microenvironment in the development of HF.
Trvalý link: https://hdl.handle.net/11104/0351444