An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis.

0583336 - ÚOCHB 2025 RIV US eng J - Článek v odborném periodiku
Jörgensen, S. K. M. - Karnošová, Alena - Mazzaferro, S. - Rowley, O. - Chen, H. J. C. - Robbins, S. J. - Christofides, S. - Merkle, F. T. - Maletínská, Lenka - Petrik, D.
An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis.
Embo Reports. Roč. 25, č. 1 (2024), s. 351-377. ISSN 1469-221X. E-ISSN 1469-3178
Institucionální podpora: RVO:61388963
Klíčová slova: adult neurogenesis * anti-obesity peptides * hypothalamus * neural stem cells * prolactin releasing peptide
Impakt faktor: 7.7, rok: 2022
Způsob publikování: Open access
https://doi.org/10.1038/s44319-023-00016-2

Hypothalamic Adult Neurogenesis (hAN) has been implicated in regulating energy homeostasis. Adult-generated neurons and adult Neural Stem Cells (aNSCs) in the hypothalamus control food intake and body weight. Conversely, diet-induced obesity (DIO) by high fat diets (HFD) exerts adverse influence on hAN. However, the effects of anti-obesity compounds on hAN are not known. To address this, we administered a lipidized analogue of an anti-obesity neuropeptide, Prolactin Releasing Peptide (PrRP), so-called LiPR, to mice. In the HFD context, LiPR rescued the survival of adult-born hypothalamic neurons and increased the number of aNSCs by reducing their activation. LiPR also rescued the reduction of immature hippocampal neurons and modulated calcium dynamics in iPSC-derived human neurons. In addition, some of these neurogenic effects were exerted by another anti-obesity compound, Liraglutide. These results show for the first time that anti-obesity neuropeptides influence adult neurogenesis and suggest that the neurogenic process can serve as a target of anti-obesity pharmacotherapy.
Trvalý link: https://hdl.handle.net/11104/0351312