STING agonist-induced CD14+ monocyte depletion involves multiple regulated cell death mechanisms

0582968 - ÚOCHB 2024 RIV CZ eng A - Abstrakt
Pimková Polidarová, Markéta - Dejmek, Milan - Hirsch, Ivan - Brázdová, Andrea - Grantz Šašková, Klára
STING agonist-induced CD14+ monocyte depletion involves multiple regulated cell death mechanisms.
Czech Chemical Society Symposium Series. Roč. 21, č. 2 (2023), s. 104. ISSN 2336-7202.
[Interdisciplinary meeting of young life scientists /22./. 15.05.2023-18.05.2023, Milovy]
Grant CEP: GA MŠMT(CZ) LX22NPO5103
Institucionální podpora: RVO:61388963
Klíčová slova: STING * cyclic dinucleotides * CD14 monocytes * regulated cell death
Obor OECD: Cell biology
http://www.ccsss.cz/index.php/ccsss/issue/view/38

The immune cells respond to the double-stranded DNA (dsDNA) or cyclic dinucleotide (CDN)-mediated stimulation of the cyclic-GMP-AMP synthase – stimulator of interferon genes (cGAS-STING) pathway by secretion of type I interferons (IFNs) and proinflammatory cytokines. STING agonists also cause a complete depletion of CD14+ monocytes in peripheral blood mononuclear cells (PBMCs). We investigate the cell death mechanisms induced by the cGAS-STING pathway activation focusing on the combination of pyroptosis, apoptosis and necroptosis, so called PANoptosis, demonstrating that CD14+ monocyte cell death could further mediate activation of secondary immune processes including the adaptive immune mechanisms.
Trvalý link: https://hdl.handle.net/11104/0351004