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An approach to pyrrolidine-containing sphingomimetics based on L-tartaricacid chiron
- 1.0582840 - ÚOCHB 2025 RIV GB eng J - Článek v odborném periodiku
Raschmanová, J. Š. - Fabián, M. - Sudzina, A. - Martinková, M. - Pilátová, M. B. - Cvačka, Josef - Kofroňová, Edita - Mezencev, R.
An approach to pyrrolidine-containing sphingomimetics based on L-tartaricacid chiron.
Tetrahedron. Roč. 153, March (2024), č. článku 133843. ISSN 0040-4020. E-ISSN 1464-5416
Institucionální podpora: RVO:61388963
Klíčová slova: sphingomimetics * pyrrolidine skeleton * heterosigmatropic rearrangement * olefin cross-metathesis reaction * anticancer profile * sphingolipids * synthesis * cancer
Obor OECD: Organic chemistry
Impakt faktor: 2.1, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.tet.2024.133843
A synthetic approach to constructing pyrrolidine-containing sphingolipid-like derivatives has been accomplished. The results obtained from biological screening have completed the structure-activity relationships in a series of eight prepared stereoisomeric C-alkyl pyrrolidinediols and elucidated the role of the stereochemistry on the heterocyclic skeleton towards the studied anticancer profile.
Trvalý link: https://hdl.handle.net/11104/0350893
Počet záznamů: 1