Ceria-Catalyzed Hydrolytic Cleavage of Sulfonamides

0582304 - ÚACH 2025 RIV US eng J - Článek v odborném periodiku
Henych, Jiří - Šťastný, Martin - Kříženecká, S. - Čundrle, Jan - Tolasz, Jakub - Dušková, T. - Kormunda, M. - Ederer, J. - Stehlík, Štěpán - Ryšánek, P. - Neubertová, V. - Janoš, P.
Ceria-Catalyzed Hydrolytic Cleavage of Sulfonamides.
Inorganic Chemistry. Roč. 63, č. 4 (2024), s. 2298-2309. ISSN 0020-1669. E-ISSN 1520-510X
Grant CEP: GA TA ČR(CZ) TH76030002; GA MŠMT(CZ) LM2023066
Institucionální podpora: RVO:61388980 ; RVO:68378271
Klíčová slova: Bond cleavage * Chemical reactions * Hydrolysis * Oxides * Reaction products
Obor OECD: Inorganic and nuclear chemistry; Nano-materials (production and properties) (FZU-D)
Impakt faktor: 4.6, rok: 2022
Způsob publikování: Open access

Nanoceria is a promising nanomaterial for the catalytic hydrolysis of a wide variety of substances. In this study, it was experimentally demonstrated for the first time that CeO2 nanostructures show extraordinary reactivity toward sulfonamide drugs (sulfadimethoxine, sulfamerazine, and sulfapyridine) in aqueous solution without any illumination, activation, or pH adjustment. Hydrolytic cleavage of various bonds, including S-N, C-N, and C-S, was proposed as the main reaction mechanism and was indicated by the formation of various reaction products, namely, sulfanilic acid, sulfanilamide, and aniline, which were identified by HPLC-DAD, LC-MS/MS, and NMR spectroscopy. The kinetics and efficiency of the ceria-catalyzed hydrolytic cleavage were dependent on the structure of the sulfonamide molecule and physicochemical properties of Nanoceria prepared by three different precipitation methods. However, in general, all three ceria samples were able to cleave SA drugs tested, proving the robust and unique surface reactivity toward these compounds inherent to cerium dioxide. The demonstrated reactivity of CeO2 to molecules containing sulfonamide or even sulfonyl (and similar) functional groups may be significant for both heterogeneous catalysis and environmentally important degradation reactions.
Trvalý link: https://hdl.handle.net/11104/0350420


Vědecká data: ACS Publications